Plotting the coloniality of conservation

Funding: NORFACE/Belmont Forum (ES/S007792/1).Contemporary and market-based conservation policies, constructed as rational, neutral and apolitical, are being pursued around the world in the aim of staving off multiple, unfolding and overlapping environmental crises. However, the substantial body of research that examines the dominance of neoliberal environmental policies has paid relatively little attention to how colonial legacies interact with these contemporary and market-based conservation policies enacted in the Global South. It is only recently that critical scholars have begun to demonstrate how colonial legacies interact with market-based conservation policies in ways that increase their risk of failure, deepen on-the-ground inequalities and cement global injustices. In this article, we take further this emerging body of work by showing how contemporary, market-based conservation initiatives extend the temporalities and geographies of colonialism, undergird long-standing hegemonies and perpetuate exploitative power relations in the governing of nature-society relations, particularly in the Global South. Reflecting on ethnographic insights from six different field sites across countries of the Global South, we argue that decolonization is an important and necessary step in confronting some of the major weaknesses of contemporary conservation and the wider socio-ecological crisis itself. We conclude by briefly outlining what decolonizing conservation might entail.Publisher PDFPeer reviewe

Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management.

Microcephaly is an important sign of neurological malformation and a predictor of future disability. The 2015-16 outbreak of Zika virus and congenital Zika infection brought the world's attention to links between Zika infection and microcephaly. However, Zika virus is only one of the infectious causes of microcephaly and, although the contexts in which they occur vary greatly, all are of concern. In this Review, we summarise important aspects of major congenital infections that can cause microcephaly, and describe the epidemiology, transmission, clinical features, pathogenesis, management, and long-term consequences of these infections. We include infections that cause substantial impairment: cytomegalovirus, herpes simplex virus, rubella virus, Toxoplasma gondii, and Zika virus. We highlight potential issues with classification of microcephaly and show how some infants affected by congenital infection might be missed or incorrectly diagnosed. Although Zika virus has brought the attention of the world to the problem of microcephaly, prevention of all infectious causes of microcephaly and appropriately managing its consequences remain important global public health priorities

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms